Severe Malaria Resources

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01 Oct 2019

[Artesunate and severe malaria in paediatrics].

Based on strong studies conducted in Asia and Africa, WHO (World Health Organization) has recommended the use of artesunate as a first-line treatment for severe malaria in adults and children since 2010.

Rev Med Liege
Peer-reviewed article
27 Sep 2019

Antimalarial Medications

Peer-reviewed article
27 Sep 2019

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it.

We are studying the role of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) expressed by asexual stages of P. falciparum responsible for the pathogenicity of severe malaria

Immunol Rev
Peer-reviewed article
18 Sep 2019

Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury.

Here, we confirm that depleting CD8T cells with anti-CD8β antibodies in C57BL/6 mice infected with P. berghei ANKA (PbA) prevent pulmonary vascular leakage. 

Nat Commun
Peer-reviewed article
18 Sep 2019

Plasmodium vivax cerebral malaria in an adult patient in Sudan.

Cases of severe malaria due to P. vivax are emerging in Africa. A few severe P. vivax cases were reported in Eastern Sudan and they were underestimated due to the lack of accurate diagnosis, low parasitaemia

Malar J
Peer-reviewed article
06 Sep 2019

Exploration of genetic diversity of Plasmodium vivax circumsporozoite protein (Pvcsp) and Plasmodium vivax sexual stage antigen (Pvs25) among North Indian isolates.

The present study was planned to study genetic diversity (Pvcsp and Pvs25) among complicated and uncomplicated P. vivax isolates.

Malar J
Peer-reviewed article
04 Sep 2019

The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia.

 Using data from cohorts including over 18,000 African children, we show that the Q248H mutation is associated with modest protection against anemia, hemolysis, and iron deficiency, but we found little evidence of protection against severe malaria or bacteremia. 

Sci Adv
Peer-reviewed article
03 Sep 2019

Severe Malaria Treatment in the United States at the Precipice.

Ann Intern Med
Peer-reviewed article
03 Sep 2019

Systematic review of artesunate pharmacokinetics: implication for treatment of resistant malaria.

Artesunate (ART) is an artemisinin derivative used as monotherapy for the treatment of severe malaria and in combination with a partner drug for non-severe malaria.

Int J Infect Dis
Peer-reviewed article
31 Aug 2019

Associations between restrictive fluid management and renal function and tissue perfusion in adults with severe falciparum malaria - a prospective observational study.

Liberal fluid resuscitation has proved harmful in adults with severe malaria, but the level of restriction has not been defined.

J Infect Dis
Peer-reviewed article
30 Aug 2019

Targeting the apicoplast in malaria.

Severe malaria is caused by the apicomplexan parasite Plasmodium falciparum Apicomplexan parasites, including the Plasmodium spp., are descendants of photosynthetic algae, and therefore they possess an essential plastid organelle, named the apicoplast. 

Biochem Soc Trans
Peer-reviewed article
28 Aug 2019

Rosetting revisited: a critical look at the evidence for host erythrocyte receptors in Plasmodium falciparum rosetting.

 This review summarizes the current understanding of the molecular interactions that lead to rosette formation, with a particular focus on host uninfected erythrocyte receptors including the A and B blood group trisaccharides, complement receptor one, heparan sulphate, glycophorin A and glycophorin C

Parasitology
Peer-reviewed article

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