Malaria continues to be a major public health concern and priority in Rwanda because it is considered one of the leading causes of morbidity and mortality. Malaria cases in Rwanda represent 1.2% of the global burden of malaria cases in 2021. The entire 12.9 million population in Rwanda is at risk for malaria and pregnant women, children under five years of age, and refugees are among the most vulnerable groups.
Between 2020 and 2021, malaria cases decreased 44%, from 227 to 126 per 1000 of the population at risk, while deaths stagnated at 0.244 per 1000 of the population at risk. Higher malaria incidence was observed in the southern districts, with concentrated pockets showing incidences greater than 450 cases per 1,000 people in 2020. In 2020, Rwanda accounted for 1.2% of global malaria cases and deaths, and 5.3% of malaria cases in East and Southern Africa. 
The MOPDD – a division within the Rwanda Biomedical Centre (RBC) under the Ministry of Health (MOH) – has developed the Rwanda Malaria Strategic Plan (MSP) covering the 2020–2024 period.
Parenteral artesunate is the recommended treatment of severe malaria for all patients except for pregnant women during the first trimester who are still recommended to receive intravenous quinine, which is NOT in line with WHO guidelines. The Rwanda national treatment guidelines were updated to include rectal artesunate indicated only as an initial (pre‐referral) intervention of severe malaria, recommended for use only in children six months to six years of age given that this management of severe malaria cases is restricted only to district, provincial and referral hospitals. The MOPDD uses RapidSMS (transitioning to RapidPro) a rapid, secure short message service (SMS) system introduced in late 2018 for coordination of severe malaria case referral from community health workers (CHWs) to health facilities.
Prevention of malaria
Rwanda has been distributing ITNs since 2006 with a view to reaching universal coverage. As part of the Extended Malaria Strategic Plan 2013–2020, the MOPDD conducted a mass campaign in 2016– 2017, which targeted all districts in the country including a top-up among the population that had not received ITNs from the 2015 distribution, to markedly increase ITN ownership.
The Malaria Indicator Survey in 2017 showed ownership of one ITN per household at 84% and universal coverage (i.e., one ITN for every two persons) at 55%. Based on these findings, the MOPDD revised its policy on ITN distribution which previously had focused on sleeping spaces to be in line with WHO guidance (i.e., one net per 1.8 people). During the most recent mass campaign in 2020, the country distributed standard and piperonyl butoxide (PBO) nets.
The Rwanda MSP 2020–2024 does not include drug-based prevention. Intermittent preventive treatment for pregnant women was discontinued in 2008 due to evidence of high-level resistance to sulfadoxine- pyrimethamine. Seasonal malaria chemoprevention and other drug-based preventive approaches are not recommended for Rwanda.
|First-line treatment||artemether-lumefantrine (AL)|
|Uncomplicated||oral quinine plus clindamycin (first trimester)|
|Uncomplicated||AL (second and third trimesters)|
|Strong||IV quinine (first trimester)|