Severe Malaria Resources

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30 Aug 2019

Targeting the apicoplast in malaria.

Severe malaria is caused by the apicomplexan parasite Plasmodium falciparum Apicomplexan parasites, including the Plasmodium spp., are descendants of photosynthetic algae, and therefore they possess an essential plastid organelle, named the apicoplast. 

Biochem Soc Trans
Peer-reviewed article
28 Aug 2019

Rosetting revisited: a critical look at the evidence for host erythrocyte receptors in Plasmodium falciparum rosetting.

 This review summarizes the current understanding of the molecular interactions that lead to rosette formation, with a particular focus on host uninfected erythrocyte receptors including the A and B blood group trisaccharides, complement receptor one, heparan sulphate, glycophorin A and glycophorin C

Parasitology
Peer-reviewed article
26 Aug 2019

The clinical profile of severe paediatric malaria in an area targeted for routine RTS,S/AS01 malaria vaccination in Western Kenya.

This study investigates clinical the profile of paediatric malaria admissions ahead of the introduction of RTS,S/AS01 vaccine.

Clin Infect Dis
Peer-reviewed article
23 Aug 2019

Acute Kidney Injury in Children with Severe Malaria Is Common and Associated with Adverse Hospital Outcomes.

The study aimed to determine the prevalence of AKI in children with severe malaria and its association with adverse hospital outcomes.

J Trop Pediatr
Peer-reviewed article
20 Aug 2019

Candidate microRNAs in Malaria Infection Biomarkers: A Systematic Review.

We aimed to do a systematic review on miRNAs serve as candidate clinical biomarkers in malaria infection

Curr Mol Med
Peer-reviewed article
14 Aug 2019

Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects.

Here, we assess the progress and pitfalls of severe malaria susceptibility GWASs and discuss the biology of the novel variants.

BMC Med Genomics
Peer-reviewed article
13 Aug 2019

Hemoglobin S and C affect biomechanical membrane properties of P. falciparum-infected erythrocytes.

Here, we combined flicker spectroscopy and a mathematical model and demonstrated that knob formation strongly suppresses membrane fluctuations by increasing membrane-cytoskeleton coupling.

Commun Biol
Peer-reviewed article
12 Aug 2019

Management of malaria in Sweden.

 This review focuses on the acute management of malaria in Sweden

Lakartidningen
Peer-reviewed article
07 Aug 2019

The treatment of malaria

In the Netherlands, approximately 200 to 300 patients are diagnosed with imported malaria every year. 

Ned Tijdschr Geneeskd
Peer-reviewed article
02 Aug 2019

Feasibility and preliminary validity evidence for remote video-based assessment of clinicians in a global health setting.

To establish preliminary inter-rater reliability, validity evidence, and feasibility for an assessment of providers who care for SCI using simulated patients and remote video capture in community clinic settings in Botswana.

PLoS One
Peer-reviewed article
01 Aug 2019

Long-term incidence of severe malaria following RTS,S/AS01 vaccination in children and infants in Africa: an open-label 3-year extension study of a phase 3 randomised controlled trial.

We aimed to investigate malaria incidence up to 7 years postvaccination in three of the sites of the initial study

Lancet Infect Dis
Peer-reviewed article
01 Aug 2019

Hemolytic anemia in pediatric patients treated with artesunate for severe malaria.

Enferm Infecc Microbiol Clin
Peer-reviewed article

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