Post-discharge malaria chemoprevention in children admitted with severe anaemia in malaria-endemic settings in Africa: a systematic review and individual patient data meta-analysis of randomised controlled trials

January 2024
Prof Kamija S Phiri MD PhD, Carole Khairallah MSc, Titus K Kwambai MD PhD, Kalifa Bojang MD PhD, Aggrey Dhabangi MD PhD, Robert Opoka MD PhD, Richard Idro MD PhD, Kasia Stepniewska PhD, Prof Michael Boele van Hensbroek PhD, Prof Chandy C John PhD, Prof Bjarne Robberstad PhD, Prof Brian Greenwood MD, Prof Feiko O ter Kuile MD PhD

Severe anaemia is associated with high in-hospital mortality among young children. In malaria-endemic areas, surviving children also have an increased risk of mortality or readmission after hospital discharge. We conducted a systematic review and individual patient data meta-analysis to determine the efficacy of monthly post-discharge malaria chemoprevention in children recovering from severe anaemia.