Severe post-artesunate delayed onset anaemia responding to corticotherapy: a case report.

01 Jan 2018
Lebrun D, Floch T, Brunet A, Julien G, Romaru J, N'Guyen Y, Cousson J, Giltat A, Toubas D, Bani-Sadr F

 

Delayed onset haemolysis occurring post-artesunate and post-artemisinin combination therapy is secondary to delayed clearance of infected erythrocytes spared by pitting during treatment. We report a case of severe post-treatment delayed haemolytic anaemia with a positive direct antiglobulin test and a positive response to corticosteroid therapy, suggesting an associated immune mechanism.