Resources

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01 Nov 2019

Intravenous Artesunate for Imported Severe Malaria in Children Treated in Four Tertiary Care Centers in Germany: A Retrospective Study.

The aim of this case series was to summarize efficacy and safety of ivA for imported severe malaria in children in Germany.

Pediatr Infect Dis J
Peer-reviewed article
Photo: MMV
21-22 Oct 2019

Severe Malaria Stakeholder Meeting, 21-22 October 2019, Abuja

The meeting brought together delegations representing 19 countries:  Angola, Benin, Burkina Faso, CAR, Congo, DRC, Ethiopia, Ghana, Liberia, Madagascar, Malawi, Mali, Mozambique, Niger, Nigeria, Sierra  Leone, Uganda, Zambia and Zimbabwe, and 15 partner organizations, including RBM, Unitaid, PMI USAID, Global Fund, UNICEF, MSH, Swiss TPH, Akena, KSPH, CRS, Makarere University, MSF, PSI, WHO and the Malaria Consortium. 

Report
22 Oct 2019

Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections.

Here, we review recent studies that have used omics-based methods to identify novel targets for interventions against protozoan parasites, focusing on malaria, and we highlight the advantages and limitations of the approaches used.

Genome Med
Peer-reviewed article
18 Oct 2019

Clinicopathological study of potential biomarkers of Plasmodium falciparum malaria severity and complications.

The present study was designed to evaluate the potential diagnostic biomarkers of P. falciparum malaria in complications.

Infect Genet Evol
Peer-reviewed article
17 Oct 2019

Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria.

We measured anti-phosphatidylserine (PS) and anti-DNA antibody levels in 382 Ugandan children prospectively recruited in a study of severe malaria (SM)

Sci Rep
Peer-reviewed article
11 Oct 2019

Transcriptional Modulation of the Host Immunity Mediated by Cytokines and Transcriptional Factors in Plasmodium falciparum-Infected Patients of North-East India.

 The transcriptional alterations of major cytokines and immunoregulators were analyzed in this study through gene expression profiling in clinically defined subgroups of P. falciparum patients.

Biomolecules
Peer-reviewed article
09 Oct 2019

Utility of qSOFA and modified SOFA in severe malaria presenting as sepsis.

We conducted a prospective observational study from March 2013 to February 2017 to examine adults admitted with community-acquired infection in a tertiary-care hospital in Ubon Ratchathani, Northeast Thailand (Ubon-sepsis).

PLoS One
Peer-reviewed article
01 Oct 2019

Severe malaria: update on pathophysiology and treatment.

We review recent advances regarding the pathophysiology of severe malaria and treatment recommendations for severe disease in the United States.

Curr Opin Infect Dis
Peer-reviewed article
01 Oct 2019

[Artesunate and severe malaria in paediatrics].

Based on strong studies conducted in Asia and Africa, WHO (World Health Organization) has recommended the use of artesunate as a first-line treatment for severe malaria in adults and children since 2010.

Rev Med Liege
Peer-reviewed article
27 Sep 2019

Antimalarial Medications

Peer-reviewed article
27 Sep 2019

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it.

We are studying the role of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) expressed by asexual stages of P. falciparum responsible for the pathogenicity of severe malaria

Immunol Rev
Peer-reviewed article
18 Sep 2019

Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury.

Here, we confirm that depleting CD8T cells with anti-CD8β antibodies in C57BL/6 mice infected with P. berghei ANKA (PbA) prevent pulmonary vascular leakage. 

Nat Commun
Peer-reviewed article

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