Resources

1
29 Apr 2019

Amino acid derangements in adults with severe falciparum malaria.

To investigate this, we prospectively simultaneously quantified a broad range of plasma free amino acids (PFAA) using HPLC-MRM-Mass spectrometry in relation to presenting symptoms in adults with severe malaria (n = 88), septicaemia (n = 88), uncomplicated malaria (n = 71), and healthy controls (n = 48) from Bangladesh.

Sci Rep
Peer-reviewed article
23 Apr 2019

Safety profile of the RTS,S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa.

We now present in-depth safety results from this study. 8922 children (enrolled at 5-17 months) and 6537 infants (enrolled at 6-12 weeks) were 1:1:1-randomized to receive 4 doses of RTS,S/AS01 (R3R) or non-malaria control vaccine (C3C), or 3 RTS,S/AS01 doses plus control (R3C).

Hum Vaccin Immunother
Peer-reviewed article
19 Apr 2019

Molecular Imaging of a Zirconium-89 Labeled Antibody Targeting Plasmodium falciparum-Infected Human Erythrocytes.

Nuclear imaging is an important preclinical research tool to study infectious diseases in vivo and could be extended to investigate complex aspects of malaria infections. As such, we report for the first time successful radiolabeling of a novel antibody specific to Plasmodium-infected erythrocytes (IIIB6), its in vitro assessment and molecular imaging in nude mice.

Mol Imaging Biol
Peer-reviewed article
17 Apr 2019

Hospital-derived antibody profiles of malaria patients in Southwest India.

A US NIH ICEMR (South Asia) team examined the level of immunity in an Indian malaria patient population visiting or admitted to Goa Medical College and Hospital in Goa, India

Malar J
Peer-reviewed article
16 Apr 2019

Clinical Impact of Malaria Rapid Diagnostic Testing at a US Children's Hospital.

We assessed the clinical impact of the implementation of malaria rapid diagnostic testing (RDT) on the management of children with malaria at an urban US children's hospital that serves a large immigrant population.

J Pediatric Infect Dis Soc
Peer-reviewed article
15 Apr 2019

Brief Report: Higher Levels of Angiopoietin-1 Are Associated With Early and Sustained Viral Suppression in Children Living With Vertically Acquired HIV.

Systemic inflammation, platelet dysfunction, and endothelial activation persist in people living with HIV despite sustained virologic suppression (SVS) with combined antiretroviral therapy (cART) and may lead to complications such as atherosclerosis and cardiovascular disease. Angiopoietin-1 (Ang-1) is a key regulator of angiogenesis and endothelial activation and has been studied as an objective biomarker in disease states such as atherosclerosis, sepsis, and severe malaria. 

J Acquir Immune Defic Syndr
Peer-reviewed article
11 Apr 2019

Association between Inflammatory Cytokine Levels and Thrombocytopenia during Plasmodium falciparum and P. vivax; Infections in South-Western Coastal Region of India.

 This study was aimed to understand the possible relationship between inflammatory cytokines across varying degrees of thrombocytopenia during P. vivax, P. falciparum, and mixed infections.

Malar Res Treat
Peer-reviewed article
11 Apr 2019

Level of knowledge among health care providers on preparation of injectable artesunate for treatment of severe malaria in public health facilities in Tanzania.

The study determined level of knowledge of health care providers (HCP) in public health facilities on the preparation of injectable artesunate for severe malaria.

BMC Res Notes
Peer-reviewed article
08 Apr 2019

Optimal Treatments for Severe Malaria and the Threat Posed by Artemisinin Resistance.

We extend existing pharmacokinetic/pharmacodynamic modeling methods to simulate the treatment of 10000 patients with severe malaria and track the pathology caused by sequestered parasites.

J Infect Dis
Peer-reviewed article
08 Apr 2019

Positive direct antiglobulin test in post-artesunate delayed haemolysis: more than a coincidence?

Delayed haemolysis is a frequent adverse event after treatment with artesunate (AS). Removing once-infected "pitted" erythrocytes by the spleen is the most accepted mechanism of haemolysis in these cases. 

Malar J
Peer-reviewed article
01 Apr 2019

C-reactive protein as a prognostic marker of Plasmodium falciparum malaria severity.

 The study was aimed to assess, if it (C-reactive protein) could serve as a predictive marker for malaria disease severity.

J Vector Borne Dis
Peer-reviewed article
01 Apr 2019

Post-malaria neurological syndrome: a rare neurological complication of malaria.

Post-malaria neurological syndrome (PMNS) is a rare self-limiting neurological complication that can occur after recovery from malaria, usually severe falciparum malaria.

Infection
Peer-reviewed article

Pages