Resources

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1 Feb 2021

Pharmacokinetic study of rectal artesunate in children with severe malaria in Africa

When severe malaria is suspected in children, WHO recommends pre-treatment with a single rectal dose of artesunate before referral to an appropriate facility. This was an individually randomized, open-label, 2-arm, cross-over clinical trial in 83 Congolese children with severe falciparum malaria, to characterize the pharmacokinetics of rectal artesunate. At admission, children received a single dose of rectal artesunate (10 mg/kg) followed 12 hours later by intravenous artesunate (2.4 mg/kg) or the reverse order. All children also received standard doses of intravenous quinine. Artesunate and dihydroartemisinin were measured at eleven fixed intervals, following 0- and 12-hour drug administrations. Clinical, laboratory and parasitological parameters were measured. 

Antimicrobial agents and Chemotherapy
Peer-reviewed article
14 Dec 2020

ASTMH 2020 Summaries from Conference Day 4

MESA Alliance
Report
05 Dec 2020

Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study

Seasonal malaria chemoprevention (SMC) aims to prevent malaria in children during the high malaria transmission season. The Achieving Catalytic Expansion of SMC in the Sahel (ACCESS-SMC) project sought to remove barriers to the scale-up of SMC in seven countries in 2015 and 2016. We evaluated the project, including coverage, effectiveness of the intervention, safety, feasibility, drug resistance, and cost-effectiveness.

The Lancet
Article
01 Dec 2020

Rectal Artesunate Information Education and Communication Report (RAISEC)

This study intended to inform future programming in relation to the role that Information – Education – Communication (IEC) could play in enhancing this continuum of care.  It hypothesized that community exposure to targeted IEC would increase early presentation by the caregiver at the village health clinic (VHC) for Rectal Artesunate (RAS) and the caregiver acceptance of RAS; and that community health worker (CHW/HSA) exposure to a targeted toolkit would increase appropriate assessment, administration of RAS and referral, and in turn enhance prompt compliance with referral instructions among caregivers.

Peer-reviewed article
Photo: Toby Madden/Transaid
19 Jun 2020

A Rapid Assessment of Severe Malaria Case Management Practices and Constraints in Angola

This study aimed to identify existing gaps in knowledge about severe malaria case management in Angola by collecting information at different health service levels and through different study populations

Medicines for Malaria Initiative
Severe malaria rapid assessment reports
20 Mar 2020

Blood group and size dependent stability of & P. falciparum & infected red blood cell aggregates in capillaries.

For related malaria (B50), one of the outstanding host factors for the development of severe disease is the ABO blood group of malaria patients, where blood group O reduces the probability of severe disease as compared to individuals of groups A, B, or AB.

Biomicrofluidics
Peer-reviewed article
16 Mar 2020

Preparedness is essential for malaria-endemic regions during the COVID-19 pandemic

Africa needs to be prepared to deal with COVID-19, given the infectious potential of the disease and its capacity to undermine malaria control efforts.

The Lancet
12 Mar 2020

Malaria Case Fatality Rate among Children under Five in Burkina Faso: An Assessment of the Spatiotemporal Trends Following the Implementation of Control Programs.

The findings of this research highlighted locations in Burkina Faso that are most in need of targeted interventions and the necessity to sustain and strengthen the launched health programs to further reduce the malaria deaths in Burkina Faso.
11 Mar 2020

Imported Malaria in Countries where Malaria Is Not Endemic: a Comparison of Semi-immune and Nonimmune Travelers.

The continuous increase in long-distance travel and recent large migratory movements have changed the epidemiological characteristics of imported malaria in countries where malaria is not endemic (here termed non-malaria-endemic countries).

Clin Microbiol Rev
Peer-reviewed article
06 Mar 2020

Optimizing iron supplementation for children with severe malaria.

The safe and efficacious provision of iron supplementation in areas of high infectious disease burden is a critical and sometimes controversial global health issue.

Am J Clin Nutr
Peer-reviewed article
03 Mar 2020

Post-artemisinin delayed hemolysis after oral therapy for P. falciparum infection.

A documented side-effect of artemisinin therapy is post-artemisinin delayed hemolysis (PADH), primarily occurring after parenteral treatment for severe P. falciparum infections.

IDCases
Peer-reviewed article
26 Feb 2020

Overexpression of Sphingosine Kinase-1 and Sphingosine-1-Phosphate Receptor-3 in Severe <i>Plasmodium falciparum</i> Malaria with Pulmonary Edema.

Pulmonary edema (PE) is a major cause of pulmonary manifestations of severe malaria and is usually associated with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

Biomed Res Int
Peer-reviewed article

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