Decoquinate liposomes: highly effective clearance of Plasmodium parasites causing severe malaria.

24 Jan 2022
Zeng S, Wang H, Tao L, Ning X, Fan Y, Zhao S, Qin L, Chen X
Severe malaria caused by Plasmodium falciparum leads to most malaria-related deaths globally. Decoquinate (DQ) displays strong activity against multistage infection by Plasmodium parasites. However, the development of DQ as an oral dosage form for the treatment of malaria at the blood stage has not been successful. In this study, liposome formulations of DQ were created for intravenous (IV) injection to suppress Plasmodium berghei, a parasite that causes severe malaria in mice.