Artesunate monotherapy versus artesunate plus quinine combination therapy for treatment of imported severe malaria: a TropNet retrospective cohort study.

01 Aug 2022
Botta A, Comelli A, Vellere I, Chechi F, Bianchi L, Giulia G, Tomasoni LR, Spinicci M, Galli L, Castelli F, Bartoloni A, Zammarchi L
The addition of intravenous quinine (IVQ) to intravenous artesunate (IVA) has been recently suggested by World Health Organization  in areas where artemisinin resistance is highly prevalent. Since IVA is not yet widely available as "Good Manufacturing Practices" product, for several years combination treatment with IVA and IVQ was used in some Italian centers to mitigate the legal risks in using an unlicensed drug.